Squamous cell skin cancer
Squamous-cell skin cancer, also known as cutaneous squamous-cell carcinoma (cSCC), is one of the main types of skin cancer along with basal cell cancer, and melanoma.[10] It usually presents as a hard lump with a scaly top but can also form an ulcer.[1] Onset is often over months.[4] Squamous-cell skin cancer is more likely to spread to distant areas than basal cell cancer.[11]
The greatest risk factor is high total exposure to ultraviolet radiation from the Sun.[2] Other risks include prior scars, chronic wounds, actinic keratosis, lighter skin, Bowen’s disease, arsenic exposure, radiation therapy, poor immune system function, previous basal cell carcinoma, and HPV infection.[2][12] Risk from UV radiation is related to total exposure, rather than early exposure.[13] Tanning beds are becoming another common source of ultraviolet radiation.[13] It begins from squamous cells found within the skin.[14] Diagnosis is often based on skin examination and confirmed by tissue biopsy.[2][3]
Decreasing exposure to ultraviolet radiation and the use of sunscreen appear to be effective methods of preventing squamous-cell skin cancer.[5][6] Treatment is typically by surgical removal.[2] This can be by simple excision if the cancer is small otherwise Mohs surgery is generally recommended.[2] Other options may include application of cold and radiation therapy.[7] In the cases in which distant spread has occurred chemotherapy or biologic therapy may be used.[7]
As of 2015, about 2.2 million people have cSCC at any given time.[8] It makes up about 20% of all skin cancer cases.[15] About 12% of males and 7% of females in the United States developed cSCC at some point in time.[2] While prognosis is usually good, if distant spread occurs five-year survival is ~34%.[4][5] In 2015 it resulted in about 51,900 deaths globally.[9] The usual age at diagnosis is around 66.[4] Following the successful treatment of one case of cSCC people are at high risk of developing further cases.[2]
Lafayette
Lafayette (/ˌlæfiˈjɛt/; French: [lafajɛt]) is a city located along the Vermilion River in southwestern Louisiana. The city of Lafayette is the fourth-largest in the state, with a population of 127,657 according to 2015 U.S. Census estimates.[2] It is the principal city of the Lafayette, Louisiana Metropolitan Statistical Area, with a 2015 estimated population of 490,488. The larger trade area or Combined Statistical Area of Lafayette-Opelousas-Morgan City CSA was 627,146 in 2015.[2] Lafayette is the parish seat of Lafayette Parish, Louisiana.[3] Its nickname is The Hub City.
The American city was founded as Vermilionville in 1821 by Jean Mouton, a French-speaking man of Acadian descent. In 1884, it was renamed for General Lafayette, who fought with and significantly aided the American Army during the American Revolutionary War.[4] The city’s economy was primarily based on agriculture until the 1940s, when the petroleum and natural gas industries became dominant.
Lafayette is considered the center of Acadiana, the area of Cajun and Creole culture in Louisiana and the United States. It developed following the relocation of Acadians after their expulsion by the British from eastern Canada in the late 18th century following France’s defeat in the Seven Years’ War. There is also a strong Louisiana Creole influence in the area.[5]